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Published Oct 31, 21
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This is a general rule for taking supplements, though. It’s not specific to butyrate. If you’re taking split doses (as in 3 capsules daily) one with each meal is a good idea. This gives your body a constant level of butyrate throughout the day and it will be able to utilize more of it.

So, split dosing is a good way to get around this. (This is, again, a general helpful tip for taking any supplement.)That said, taking butyrate consistently, every day for a period of weeks or months is how you’ll get the best results. So, if you find you can only remember once each day, then just take your entire daily dose at one time.

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There hasn’t been enough research yet to establish an official upper limit. Most clinical trials, however, use a dose of around 300 mg daily. These studies have proven this dose to be safe and effective at improving digestive function and healing leaky gut symptoms. Be aware that it will likely take a couple of weeks for your symptoms to improve.

Since there’s no agreement on what the upper dosage of butyrate should be, many supplements come in higher doses than 300 mg. Try to choose a supplement that gets you close to this dose though, to ensure you’re getting a safe and effective amount of this healthy fatty acid. Most of your butyrate requirement is taken care of by the .

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Of course, you can also take a butyrate supplement to boost your levels of this vital nutrient. Supplementation is a guaranteed way of getting the right dose, every day. I already touched on the actions of butyrate that really make it useful for a leaky gut — it’s anti-inflammatory, immune-modulating, and cell regenerating.

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So, anything that reduces inflammation in your gut is going to help reverse this condition and let your gut wall rebuild itself. The cells of your intestines are some of the fastest growing cells in your body. So, the minute you remove the cause of damage, your gut will start to repair itself.

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Your gut wall can return to its normal, healthy state, with a thick layer of cells between your gut contents and your bloodstream. And the important barrier function of your gut wall is strengthened. Incredibly, there have been no negative side effects noted from butyrate supplementation when it’s used at a reasonable dose.

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Can you supplement butyrate?

You can also take butyric acid as a supplement. Sodium butyrate is one of the most common forms of the supplement. You can buy this supplement at most health stores or online.

Are butyrate supplements effective?

These results suggest that butyrate supplementation may be beneficial for the treatment of metabolic diseases in which exaggerated inflammation plays an important role such as diabetes, atherosclerosis and gout

What is butyrate used for?

Butyrate functions as a “HDAC inhibitor”, meaning that it performs anticancer and anti-inflammatory functions by suppressing the activity of specific immune cells. These functions are believed to contribute to its role in preventing colorectal cancer and inflammation

I can’t see anything wrong with that!)It’s worth noting that animal studies have shown side effects at very high doses, including swelling of the kidneys and destruction of gut cells. But the dosage range for these side effects would be around 7-8 grams, daily, in humans. This is about 25 times the dose of 300 mg daily we’re recommending.

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Many cheap supplements are sold without thoroughly testing the product. You need to know that the butyrate you’re buying contains the amount of active ingredient it claims to. Independent testing also lets you make sure that the supplement isn’t contaminated with any other chemicals. Finally, it’s always a good idea to check product reviews and customer feedback to find out what other people’s experiences have been.



With 100 capsules in each bottle, a single bottle will last you around 3 months. Healus Tri-Butyrate stands out as the most convenient, most effective butyrate capsule you can buy. Like Butycaps granules below, Healus deliver their butyrate in tributyrin form, the natural form of this fatty acid found in butter.

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With 500 mg of pure butyrate in each capsule, this is an easy one-a-day way to get a decent dose of this short-chain fatty acid. Each bottle contains 60 capsules so it’s at the more expensive end of the scale. But the price reflects the quality of this product. If you’ve tried other supplements and found they didn’t give you the result you were hoping for, this product is definitely worth trying.

The butyrate in this formula is delivered in tributyrin form and held in micro-encapsulated granules. If you have severe digestive issues and you’re concerned about whether your digestion is strong enough to break down a capsule or tablet, then Butycaps is the supplement for you. Butycaps doesn’t win prizes for convenience or taste but it makes up for that by being the best option available if you have a poor digestive function.

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You might want to use the granules for the first 1-3 months until you start to see an improvement in your digestive function. And after that, you could switch to something more convenient, like the capsules above. You only get one-month supply in each box of Butycaps, so it’s definitely not the most economical choice.

The net result of supplementing with butyrate is that your gut wall gets stronger, healthier, and more able to do its job.

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